We have previously demonstrated that riluzole has anxiolytic-like effects in rats, without affecting spontaneous alternation performance in the Y-maze test.However, the effects of riluzole on hippocampal synaptic plasticity were still unclear.In this read more study, we showed that bath application of riluzole did not impair long-term potentiation and long-term depression, whereas a hacklinkci.com benzodiazepine anxiolytic, diazepam, significantly impaired them.
Furthermore, the acquisition of spatial memory in the Morris water maze test was impaired in diazepam-treated but not riluzole-treated rats.We thus provide further evidence for the potential usefulness of riluzole as an anxiolytic that does not cause amnesia.Keywords:: mood and anxiety disorder, amnesia, riluzole.